I'm jealous (even though I'll be in BC around that time).
I've never been to Portland, but I sent my inlaws to Pelican on the coast. It's consistently rated as one of Oregon's best brew pubs. The inlaws loved it & grabbed me some bottles.
There's way to much to see & do in Seattle (even just beer-wise). I liked Pike street as well, and you'll probably want to check out the market anyway. Collin's is a decent little place to sample & the food is a step up from typical pub grub. You obviously have to go to Bottleworks. I've never made it to their cafe though.
If you're driving up north, there's a couple of great stops. Diamond Knot in Mukilteo makes some solid brews. Boundary Bay in Bellingham is pretty good (too bad the bottleshoppe closed). There's a few other places I've never been... LaConner for one.
Though if you're considering Victoria at all, rather than driving inland, you could take a few ferries and check out Water Street Brewing in port townsend & a couple other stops along the way to Victoria. Some nice country & some nice brews along the way. I love Victoria (and the island in general), but after Portland & Seattle, it might be a bit of a let down.
I've never made it to this place along the Mt. Baker Highway, but it looks interesting (brewery, pizzeria, wedding chapel & beer shrine!):
Actually, Mt. Baker is a great place to ski/snowboard as well. It's not as touristy as Whistler & they get a lot of snow fall. I haven't been there in almost a decade, but they were still using diesel lifts without safety bars. It was wicked (they'd close some down if it got too windy).